The aim of this study is to identify the impact of E-government applications on the decision- making effectiveness, in the Jordanian Ministry of Interior. The study population consisted of (297) employees of the occupants of administrative positions at the Ministry, researchers studied all the community by distributing (297) questionnaires, (270) valid questionnaires were recovered. The study found that there is a significant effect of E-government applications on the effectiveness of the administrative decision-making in the Jordanian Ministry of Interior. The study recommended Ministry of Interior to increase using E-government applications in all levels and functions, and reinforce using of E-government applications in decision making with all its stages to enhance decisions effectiveness. Key Words: E-Government, Decision-Making Effectiveness, Ministry of Interior, Jordan.