Multinational companies’ (MNCs) activities in SSA countries could generate more value to the local economy if appropriate cooperation strategies are implemented for the benefit of both sides. We have analyzed the activities of MNCs in SSA countries, their capabilities and interests, and proposed strategies for the SSA side that could create more values for both sides. For each potential business opportunity, we have proposed a relevant cooperation strategy that could generate value for both sides. We found a wide range of projects that could improve the value generated for both sides in energy, agriculture, infrastructure, food processing, cosmetics, and health products. We can develop similar projects in many other SSA countries and use similar cooperation strategies. Those models could be adapted to other developing countries. MNCs with the relevant cooperation strategies, supported by local partners in SSA countries, could generate a broader value to share for the benefit of many. Keywords: Agriculture, Cooperation, Cosmetics, Energy, Globalization, Minerals, MNC.