At the present time, because of competition between organizations, empowerment of employees is considered as primary needs of any organization. Employees who have high ability of job performance will find their actual position in the organization and are looking for opportunities. One of the effects of empowerment is innovative performance. This study sought to examine the relationship between human resource empowerment and innovative performance in vocational training of Guilan. Also the effects of three variables of leadership style, culture and creativity on empowering employees are examined. The present study as its purpose, targets applied type and the statistical population of research are employees of vocational trainings of Guilan province that using non-random analytical sampling method, number of 110 employees were selected as the statistical population. Total number of 110 questionnaires was distributed among the population. 10 questionnaires were returned that adjustment of the numbers with Morgan table confirms sample size to be appropriate. Necessary data were collected through questionnaire. To analyze the data, Pearson correlation coefficient and to test normality, Kolmogorov-Simirnov test was used. Also Friedman test for ranking influence of variables of culture, creativity and leadership style were used. Key Words: Empowerment, Innovative Performance, Innovation, Guilan Vocational.