This study aims at discussing the reality and constraints of the application of e-learning at Al-Najah National University from the perspective of faculty members in colleges. In order to achieve the study objectives, the researchers conducted the study on a sample of (50) of faculty members at the faculty of economy and administrative sciences in an Najah national university. The researchers found a group of problems that encounter the implementing of e-learning. The study results reveal that many academics complain that they are ill equipped to utilize new technologies in teaching. Technology-based teaching is time consuming, leads to increasing workload, and demands high levels of technical support. Some academics in higher education institutions do not recognize the time effort spent in implementing web-based teaching and preparing computer-generated instructional materials. Key Words: E-Learning, Cultural Challenges, Language Barriers, Technology Higher Education E Learning, Blended Learning, University Instructors, Challenges.