The study aimed to identify the direct and indirect effect of top management support on innovation through the synergy between organizational structure and information technology. Data were collected from 210 industrial companies. Structural Equation Modeling (SEM) was used to test the hypotheses of the study. In addition, Confirmatory Factor Analysis (CFA analysis) was used to test the validity and reliability of the study instrument. The study concluded that the support of top management affect innovation (product innovation and process innovation). Furthermore, the results showed that top management support affects the synergy between organizational structure and information technology. It was also found that the synergy between organizational structure and information technology affect innovation (product innovation and process innovation). Finally, the study revealed that the synergy between organizational structure and information technology does not mediate the effect of top management support in innovation (product innovation, process innovation). Key Words: Leadership, Process Innovation, Product Innovation, Organizational Structure, Information Technology, Synergy, Structural Analysis.