This study examines the effect of Entrepreneurial business operation on the economic survival of the Nigeria people in Ilorin Metropolitan area. Random sampling techniques was used, from which the sample of various SMEs Owners (Entrepreneurs) was drawn through the simple random sampling, a sample of (50) Entrepreneur were selected from a list of registered SMEs-Owner in Ilorin. Fifty (50) Questionnaires were administered and distributed to the Entrepreneurs across the South local government in Ilorin. The responses were analyzed using Statistical Package for Social Sciences (SPSS) analytical package. The results of the research show that small scale business operation has a positive and significant effect on the economy Survival. From the analysis carried out and the data obtained from this research work, the result validates that Small scale business operations contribute to the economic growth of a nation. Also, there is a significant relationship between entrepreneurial business operations and the productivity. Establishment of small scale businesses brings at least 50% increase in profitability and productivity has the age of the business increase. There is positive relationship between small scale business and employment. The higher the small scale business established the more employment of youths increase. Key Words: Small and medium scale Business, Business Orientation, Entrepreneurial, Economic; Ilorin, Nigeria.