The purpose of this paper is to develop an understanding of entrepreneurs decision-making when they are faced with risky conditions at the time of opportunity discovery. Thus, in an experimental study, we compared two groups of entrepreneurs and non-entrepreneurs according to their manners of decision-making. The study draws on an internet-based survey sent in December 2013 to 120 adults (60 entrepreneurs and 60 non-entrepreneurs). Entrepreneurs were from different small businesses in three different industries. Participants were randomly assigned to three different non-entrepreneurial tasks of life and death, investment and time plus one entrepreneurial opportunity task. All the tasks were designed based on risky choice framing in negative vs. positive conditions. Results show that entrepreneurs are impervious to framing effects in opportunity scenario and show very little inconsistency in risk seeking behavior in both negative and positive conditions. Key Words: Cognitive biases, Entrepreneurial Opportunity, Framing Effects, Judgment and decision-making.